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Basal Forebrain Mediated Increase in Brain CRF is Associated with Increased Cholinergic Tone and Depression

Gollan, JK and Dong, H and Bruno, D and Nierenberg, J and Nobrega, JN and Grothe, MJ and Pollock, BG and Marmar, CR and Teipel, S and Csernansky, JG and Pomara, N (2017) Basal Forebrain Mediated Increase in Brain CRF is Associated with Increased Cholinergic Tone and Depression. 'Psychiatry Research: Neuroimaging. ISSN 0925-4927

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Abstract

Major depression is a devastating disease that generates significant suffering and cost.
After controlling for the main effects of diagnosis and Cerebrospinal Fluid Corticotropin-Releasing Factor (CSF CRF), the interaction between CSF CRF and major depression disorder diagnosis was a significant predictor of basal forebrain cholinergic nuclei volume, but not of hippocampal volume.
By investigating both markers concurrently in participants with and without depression, we describe the extent to which the interaction between CSF CRF levels and depression diagnosis is associated with the volume of the forebrain cholinergic nuclei and of the hippocampus.
These results contribute to our understanding of the role of brain’s stress axis in depression.

Item Type: Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Natural Sciences and Psychology
Publisher: Elsevier
Date Deposited: 25 Apr 2017 08:58
Last Modified: 13 Sep 2017 10:23
DOI or Identification number: 10.1016/j.pscychresns.2017.04.009
URI: http://researchonline.ljmu.ac.uk/id/eprint/6277

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