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NanoSOSG: A Nanostructured Fluorescent Probe for the Detection of Intracellular Singlet Oxygen

Ruiz-Gonzalez, R and Bresoli-Obach, R and Gulias, O and Agut, M and Savoie, H and Boyle, RW and Nonell, S and Giuntini, F (2017) NanoSOSG: A Nanostructured Fluorescent Probe for the Detection of Intracellular Singlet Oxygen. Angewandte Chemie-International Edition, 56 (11). pp. 2885-2888. ISSN 1433-7851

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Abstract

A biocompatible fluorescent nanoprobe for singlet oxygen (1O2) detection in biological systems was designed, synthesized, and characterized, that circumvents many of the limitations of the molecular probe Singlet Oxygen Sensor Green® (SOSG). This widely used commercial singlet oxygen probe was covalently linked to a polyacrylamide nanoparticle core using different architectures to optimize the response to 1O2. In contrast to its molecular counterpart, the optimum SOSG-based nanoprobe, which we call NanoSOSG, is readily internalized by E. coli cells and does not interact with bovine serum albumin. Furthermore, the spectral characteristics do not change inside cells, and the probe responds to intracellularly generated 1O2 with an increase in fluorescence.

Item Type: Article
Additional Information: This is the accepted version of the following article: R. Ruiz-González, R. Bresolí-Obach, Ò. Gulías, M. Agut, H. Savoie, R. W. Boyle, S. Nonell, F. Giuntini, NanoSOSG: A Nanostructured Fluorescent Probe for the Detection of Intracellular Singlet Oxygen Angew. Chem. Int. Ed. 2017, 56, 2885., which has been published in final form at http://dx.doi.org/10.1002/anie.201609050
Uncontrolled Keywords: 03 Chemical Sciences
Subjects: Q Science > QD Chemistry
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 26 Apr 2017 10:18
Last Modified: 06 Sep 2017 23:04
DOI or Identification number: 10.1002/anie.201609050
URI: http://researchonline.ljmu.ac.uk/id/eprint/6296

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