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pH-triggered drug release from biodegradable microwells for oral drug delivery.

Nielsen, LH and Nagstrup, J and Gordon, S and Keller, SS and Østergaard, J and Rades, T and Müllertz, A and Boisen, A (2015) pH-triggered drug release from biodegradable microwells for oral drug delivery. Biomedical Microdevices, 17 (3). ISSN 1572-8781

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Abstract

Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm. The microwells were filled with ASSF using a modified screen printing technique, followed by coating of the microwell cavities with a gastro-resistant lid of Eudragit® L100. The release behavior of ASSF from the coated microwells was investigated using a μ-Diss profiler and a UV imaging system, and under conditions simulating the changing environment of the gastrointestinal tract. Biorelevant gastric medium (pH 1.6) was employed, after which a change to biorelevant intestinal release medium (pH 6.5) was carried out. Both μ-Diss profiler and UV imaging release experiments showed that sealing of microwell cavities with an Eudragit® layer prevented drug release in biorelevant gastric medium. An immediate release of the ASSF from coated microwells was observed in the intestinal medium. This pH-triggered release behavior demonstrates the future potential of PLLA microwells as a site-specific oral drug delivery system.

Item Type: Article
Additional Information: The final publication is available at Springer via http://dx.doi.org/10.1007/s10544-015-9958-5
Uncontrolled Keywords: 0903 Biomedical Engineering, 0912 Materials Engineering
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Springer Verlag
Related URLs:
Date Deposited: 05 Jun 2017 11:24
Last Modified: 05 Jun 2017 11:24
DOI or Identification number: 10.1007/s10544-015-9958-5
URI: http://researchonline.ljmu.ac.uk/id/eprint/6627

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