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Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health

Wheeler, MJ and Dempsey, PC and Grace, MS and Ellis, KA and Gardiner, PA and Green, DJ and Dunstan, DW (2017) Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3 (3). pp. 291-300. ISSN 2352-8737

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Abstract

Cognitive decline leading to dementia represents a global health burden. In the absence of targeted pharmacotherapy, lifestyle approaches remain the best option for slowing the onset of dementia. However, older adults spend very little time doing moderate to vigorous exercise and spend a majority of time in sedentary behavior. Sedentary behavior has been linked to poor glycemic control and increased risk of all-cause mortality. Here, we explore a potential link between sedentary behavior and brain health. We highlight the role of glycemic control in maintaining brain function and suggest that reducing and replacing sedentary behavior with intermittent light-intensity physical activity may protect against cognitive decline by reducing glycemic variability. Given that older adults find it difficult to achieve current exercise recommendations, this may be an additional practical strategy. However, more research is needed to understand the impact of poor glycemic control on brain function and whether practical interventions aimed at reducing and replacing sedentary behavior with intermittent light intensity physical activity can help slow cognitive decline.© 2017 The Authors

Item Type: Article
Subjects: B Philosophy. Psychology. Religion > BF Psychology
G Geography. Anthropology. Recreation > GV Recreation Leisure
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Elsevier
Date Deposited: 09 Jun 2017 10:41
Last Modified: 06 Sep 2017 13:30
DOI or Identification number: 10.1016/j.trci.2017.04.001
URI: http://researchonline.ljmu.ac.uk/id/eprint/6675

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