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TTN genotype is associated with fascicle length and marathon running performance.

Stebbings, GK and Williams, AG and Herbert, AJ and Lockey, SJ and Heffernan, SM and Erskine, RM and Morse, CI and Day, SH (2017) TTN genotype is associated with fascicle length and marathon running performance. Scandinavian Journal of Medicine and Science in Sports. ISSN 1600-0838

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Abstract

Titin provides a molecular blueprint for muscle sarcomere assembly and sarcomere length can vary according to titin isoform expression. If variations in sarcomere length influence muscle fascicle length, this may provide an advantage for running performance. Thus the aim of this study was to investigate if the titin (TTN) rs10497520 polymorphism was associated with muscle fascicle length in recreationally active men (RA; n = 137) and marathon personal best time in male marathon runners (MR; n = 141). Fascicle length of the vastus lateralis was assessed in vivo using B-mode ultrasonography at 50% of muscle length in RA. All participants provided either a whole blood, saliva or buccal cell sample, from which DNA was isolated and genotyped using real-time polymerase chain reaction. Vastus lateralis fascicle length was 10.4% longer in CC homozygotes, those carrying two copies of the C-allele, than CT heterozygotes (p = 0.003) in RA. In the absence of any TT homozygotes, reflective of the low T-allele frequency within Caucasian populations, it is unclear if fascicle length for this group would have been smaller still. No differences in genotype frequency between the RA and MR groups were observed (p = 0.500), although within the MR group the T-allele carriers demonstrated marathon personal best times 2 min 25 s faster than CC homozygotes (p = 0.020). These results suggest that the T-allele at rs10497520 in the TTN gene is associated with shorter skeletal muscle fascicle length and conveys an advantage for marathon running performance in habitually trained men. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This is the accepted version of the following article: Stebbings, G. K., Williams, A. G., Herbert, A. J., Lockey, S. J., Heffernan, S. M., Erskine, R. M., Morse, C. I. and Day, S. H. (), TTN genotype is associated with fascicle length and marathon running performance. Scand J Med Sci Sports. Accepted Author Manuscript. doi:10.1111/sms.12927, which has been published in final form at http://dx.doi.org/10.1111/sms.12927
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 09 Jun 2017 11:23
Last Modified: 13 Sep 2017 10:27
DOI or Identification number: 10.1111/sms.12927
URI: http://researchonline.ljmu.ac.uk/id/eprint/6680

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