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Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men.

Chasland, LC and Knuiman, MW and Divitini, ML and Chan, YX and Handelsman, DJ and Naylor, LH and Green, DJ and Yeap, BB (2017) Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men. Clinical Endocrinology. ISSN 0300-0664

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Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men..pdf - Accepted Version
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Abstract

CONTEXT: Male ageing is associated with lower circulating testosterone (T) and increased incidence of cardiovascular disease (CVD). Whether physical activity (PA) interacts with hormones to modify CVD risk is unclear. OBJECTIVE: We assessed whether PA and sex hormone concentrations were independently associated with measures of CVD risk. PARTICIPANTS: 1,649 men. METHODS: Leisure, home, work and total PA were ascertained. At baseline, serum T, dihydrotestosterone (DHT) and estradiol (E2) were assayed. Men were stratified into high PA+high hormone (H/H); low PA+high hormone (L/H); high PA+low hormone (H/L) and low PA+low hormone (L/L). RESULTS: Mean age was 49.8 years at outset with 415 CVD events and 127 CVD deaths occurring during 20-year follow-up. Men with higher PA and higher T or DHT had lower odds of metabolic syndrome (eg. leisure H/H vs L/L odds ratio [OR] 0.17 p<0.001 for T, 0.26 p<0.001 for DHT). Men with higher PA and E2 had lower risk of metabolic syndrome (eg. leisure PA H/H vs L/L OR 0.51, p=0.001). Men with higher leisure, work or total PA and higher DHT had the lowest risk of CVD death (eg. leisure H/H HR 0.55 vs L/L, p=0.033). Men with lower leisure, home or work PA and higher E2 were at greater risk of CVD death (eg. leisure L/H HR 1.60 vs L/L, p=0.039). CONCLUSIONS: Considering T, DHT and E2 in the context of PA better informs consideration of cardiovascular risk. A 2x2 factorial RCT assessing PA and androgens would illuminate the scope for preventing CVD in men. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This is the accepted version of the following article: Chasland, L. C., Knuiman, M. W., Divitini, M. L., Chan, Y. X., Handelsman, D. J., Naylor, L. H., Green, D. J. and Yeap, B. B. (), Greater physical activity and higher androgen concentrations are independently associated with lower cardiometabolic risk in men. Clin Endocrinol. Accepted Author Manuscript. doi:10.1111/cen.13407, which has been published in final form at http://dx.doi.org/10.1111/cen.13407
Uncontrolled Keywords: 1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 05 Jul 2017 09:05
Last Modified: 13 Sep 2017 10:04
DOI or Identification number: 10.1111/cen.13407
URI: http://researchonline.ljmu.ac.uk/id/eprint/6781

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