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The Sirtuin Family Members SIRT1, SIRT3 and SIRT6: Their Role In Vascular Biology and Atherogenesis

Sosnowska, B and Mazidi, M and Penson, P and Gluba-Brzozka, A and Rysz, J and Banach, M (2017) The Sirtuin Family Members SIRT1, SIRT3 and SIRT6: Their Role In Vascular Biology and Atherogenesis. Atherosclerosis. ISSN 0021-9150

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Abstract

The sirtuins, silent mating-type information regulation 2 (SIRTs), are a family of nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases with important roles in regulating energy metabolism and senescence. Activation of SIRTs appears to have beneficial effects on lipid metabolism and antioxidants, prompting investigation of the roles of these proteins in atherogenesis. Although clinical data are currently limited, the availability and safety of SIRT activators such as metformin and resveratrol provide an excellent opportunity to conduct research to better understand the role of SIRTs in human atherosclerosis. Encouraging observations from preclinical studies necessitate rigorous large, prospective, randomized clinical trials to determine the roles of SIRT activators on the progression of atherosclerosis and ultimately on cardiac outcomes, such as myocardial infarction and mortality.

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences, 1102 Cardiovascular Medicine And Haematology
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 29 Aug 2017 10:11
Last Modified: 29 Aug 2017 10:11
DOI or Identification number: 10.1016/j.atherosclerosis.2017.08.027
URI: http://researchonline.ljmu.ac.uk/id/eprint/6987

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