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The impact of cigarette/e-cigarette vapour on simulated pulmonary surfactant monolayers under physiologically relevant conditions

Davies, MJ and Birkett, JW and Kotwa, M and Tomlinson, L and Woldtinsae, R (2017) The impact of cigarette/e-cigarette vapour on simulated pulmonary surfactant monolayers under physiologically relevant conditions. Surface and Interface Analysis. ISSN 1096-9918

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Abstract

Deviation in pulmonary surfactant structure–function activity can impair airway patency and lead to respiratory disorders. This novel study aims to evaluate the influence cigarette/e-cigarette vapour has on model surfactant films located within a simulated pulmonary environment using a lung biosimulator. Chromatographic analysis confirmed that nicotine levels were consistent with the sampling regimen employed. On exposure to smoke vapour, Langmuir isotherms exhibited condensed character and a significant reduction in maximum surface pressure was noted in all cases. Langmuir isocycles, reflective of the human breathing cycle, demonstrated condensed character on smoke vapour delivery. A reduction in themaximumsurface pressure was clear only in the case of cigarette vapour application. The components of cigarette vapour can cause oxidative damage to pulmonary surfactant and impair recycling. Neutral nicotine molecules can weaken the structure of the monolayer and cause destabilisation. A protective effect was evident in the case of repeated surfactant compression – relaxation cycles (i.e. the ability to reduce the surface tension term was impaired less), demonstrating a likely innate biological defensive mechanism of the lung. E-cigarette vapour appeared to have a reduced impact on surfactant performance, which may hold value in harm reduction over the longer term.

Item Type: Article
Additional Information: This is the accepted version of the following article: Davies, M. J., Birkett, J. W., Kotwa, M., Tomlinson, L., and Woldetinsae, R. (2017) The impact of cigarette/e-cigarette vapour on simulated pulmonary surfactant monolayers under physiologically relevant conditions. Surf. Interface Anal., doi: 10.1002/sia.6205., which has been published in final form at http://dx.doi.org/10.1002/sia.6205
Uncontrolled Keywords: 0306 Physical Chemistry (Incl. Structural), 0204 Condensed Matter Physics
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: John Wiley & Sons Inc.
Date Deposited: 25 Sep 2017 15:01
Last Modified: 25 Sep 2017 15:01
DOI or Identification number: 10.1002/sia.6205
URI: http://researchonline.ljmu.ac.uk/id/eprint/7213

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