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Autophagy regulated by lncRNA HOTAIR contributes to the cisplatin-induced resistance in endometrial cancer cells

Sun, M-Y and Zhu, J-Y and Zhang, C-Y and Zhang, M and Song, Y-N and Rahman, K and Zhang, L-J and Zhang, H (2017) Autophagy regulated by lncRNA HOTAIR contributes to the cisplatin-induced resistance in endometrial cancer cells. Biotechnology Letters, 39 (10). pp. 1477-1484. ISSN 0141-5492

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Abstract

Objectives: To identify whether lncRNAs (long non-coding RNA) participate in the regulation of cisplatin-resistant induced autophagy in endometrial cancer cells.
Results: Autophagy activity was significantly boosted in cisplatin-resistant Ishikawa cells, a human endometrial cancer cell line, compared with that in parental Ishikawa cells. After analyzing the overall long noncoding RNA (lncRNA) profiling, a meaningful lncRNA, HOTAIR, was identified. It was down-regulated simultaneously in cisplatin-resistant Ishikawa cells and parental Ishikawa cells treated with cisplatin. RNA interference of HOTAIR reduced the proliferation of cisplatin-resistant Ishikawa cells and enhanced the autophagy activity of cisplatin-resistant Ishikawa cells with or without cisplatin treatment, in addition, beclin-1, multidrug resistance (MDR), and P-glycoprotein (P-gp) were mediated by lncRNA HOTAIR.
Conclusions: It is clear that lncRNAs, specifically HOTAIR, can regulate the cisplatin-resistance ability of human endometrial cancer cells through the regulation of autophagy by influencing Beclin-1, MDR, and P-gp expression.

Item Type: Article
Additional Information: The final publication is available at link.springer.com via http://dx.doi.org/10.1007/s10529-017-2392-4
Uncontrolled Keywords: 06 Biological Sciences, 09 Engineering, 10 Technology
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Springer
Related URLs:
Date Deposited: 10 Oct 2017 11:19
Last Modified: 10 Oct 2017 11:19
DOI or Identification number: 10.1007/s10529-017-2392-4
URI: http://researchonline.ljmu.ac.uk/id/eprint/7319

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