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Polyphenols and Microvascular Function in Humans: A Systematic Review.

Woodward, KA and Draijer, R and Thijssen, DHJ and Low, DA Polyphenols and Microvascular Function in Humans: A Systematic Review. Current Pharmaceutical Design, 23. ISSN 1381-6128 (Accepted)

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Abstract

BACKGROUND: Polyphenol-rich dietary sources are acknowledged to have potential cardiovascular health benefits, particularly in reducing cardiovascular disease risk. METHODS: This systematic review sought to determine the effect of polyphenol-rich foods and beverages upon microvascular function, which is of considerable importance in its contribution towards the pathophysiology of microvascular-related complications but also in the future development of (macro-vessel) cardiovascular disease. RESULTS: Overall, consumption of polyphenol-rich foods and beverages demonstrate improved microvascular function, although this is dependent upon the polyphenol source, the dose of the product, the duration of consumption and the population group studied. Most subgroups reviewed suggest an overall beneficial effect on microvascular function, particularly grape-derived products, cocoa, tea, pine bark and Rutaceae aurantiae. Other groups remain equivocal and require further study due to the limited research performed to date. CONCLUSION: Polyphenols are abundant in the human diet and this systematic review demonstrates that they are an inexpensive, non-pharmacological approach for improving cardiovascular health in currently healthy individuals and in populations with microvascular dysfunction.

Item Type: Article
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Divisions: Sport & Exercise Sciences
Publisher: Bentham Science Publishers
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Date Deposited: 14 Nov 2017 13:54
Last Modified: 14 Nov 2017 13:54
DOI or Identification number: 10.2174/1381612823666171109103939
URI: http://researchonline.ljmu.ac.uk/id/eprint/7547

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