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A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training.

Srisawat, K and Shepherd, SO and Lisboa, PJ and Burniston, JG (2017) A Systematic Review and Meta-Analysis of Proteomics Literature on the Response of Human Skeletal Muscle to Obesity/Type 2 Diabetes Mellitus (T2DM) Versus Exercise Training. Proteomes, 5 (4). ISSN 2227-7382

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Abstract

We performed a systematic review and meta-analysis of proteomics literature that reports human skeletal muscle responses in the context of either pathological decline associated with obesity/T2DM and physiological adaptations to exercise training. Literature was collected from PubMed and DOAJ databases following PRISMA guidelines using the search terms 'proteom*', and 'skeletal muscle' combined with either 'obesity, insulin resistance, diabetes, impaired glucose tolerance' or 'exercise, training'. Eleven studies were included in the systematic review, and meta-analysis was performed on a sub-set (four studies) of the reviewed literature that reported the necessary primary data. The majority of proteins (n = 73) more abundant in the muscle of obese/T2DM individuals were unique to this group and not reported to be responsive to exercise training. The main response of skeletal muscle to exercise training was a greater abundance of proteins of the mitochondrial electron transport chain, tricarboxylic acid cycle and mitochondrial respiratory chain complex I assembly. In total, five proteins were less abundant in muscle of obese/T2DM individuals and were also reported to be more abundant in the muscle of endurance-trained individuals, suggesting one of the major mechanisms of exercise-induced protection against the deleterious effects of obesity/T2DM occurs at complex I of the electron transport chain.

Item Type: Article
Uncontrolled Keywords: Preferred Reporting items for Systematic Review and Meta-analyses (PRISMA); high intensity exercise; insulin resistance; mass spectrometry; meta-analysis (MA); obese; protein abundance; systematic review (SR); type 2 diabetes
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Applied Mathematics
Sport & Exercise Sciences
Publisher: MDPI
Related URLs:
Date Deposited: 23 Nov 2017 10:43
Last Modified: 23 Nov 2017 10:43
DOI or Identification number: 10.3390/proteomes5040030
URI: http://researchonline.ljmu.ac.uk/id/eprint/7587

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