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Association of Exercise Preconditioning With Immediate Cardioprotection: A Review.

Thijssen, DHJ, Redington, A, George, KP, Hopman, MTE and Jones, H (2017) Association of Exercise Preconditioning With Immediate Cardioprotection: A Review. JAMA Cardiology. ISSN 2380-6583

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Abstract

Importance: Exercise reduces the risk of cardiovascular events, including through an underrecognized, clinically useful form of acute cardioprotection accessible after a single episode of exercise, which is called cardiovascular preconditioning. Observations: Preclinical evidence shows that 1 to 3 episodes of exercise per week will provide strong cardioprotection; gradual, modest cardiovascular risk factor modification or physiological artery remodeling cannot fully explain these benefits. This review highlights preclinical evidence that acute exercise-induced cardiac preconditioning has the ability to activate multiple pathways to confer immediate protection against ischemic events, reduce the severity of potentially lethal ischemic myocardiac injury, and act as a physiological first line of defense. Conclusions and Relevance: Independent of the protective benefits of long-term exercise training on risk factors and adaptation of the cardiovascular system, cardiovascular preconditioning may contribute to the immediate cardioprotection of exercise. In practical terms, this means that 1 episode of exercise can create clinically relevant cardioprotection.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American Medical Association
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Date Deposited: 08 Dec 2017 13:36
Last Modified: 08 Dec 2017 13:36
DOI or Identification number: 10.1001/jamacardio.2017.4495
URI: http://researchonline.ljmu.ac.uk/id/eprint/7689

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