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Acute Impact of Different Exercise Modalities on Arterial and Platelet Function.

Haynes, A, Linden, MD, Robey, E, Watts, GF, Barrett, PHR, Naylor, LH and Green, DJ (2017) Acute Impact of Different Exercise Modalities on Arterial and Platelet Function. Medicine & Science in Sports & Exercise. ISSN 0195-9131

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Abstract

PURPOSE: Acute coronary syndromes and ischemic stroke are associated with arterial events involving platelets, the endothelium and atherosclerosis. Whilst regular physical activity is associated with lower risk of cardiovascular events and mortality, risk is transiently increased during and immediately following participation in an acute bout of exercise. No previous study has investigated the acute impact of exercise on platelet activation and arterial function in the same participants; it is also unknown if responses are dependent on exercise modality. We hypothesised that commonly adopted, yet physiologically distinct, modalities of exercise ("aerobic" versus "resistance") have differing effects on in vivo platelet activation and conduit artery diameter. METHODS: Eight apparently healthy middle-aged (53.5±1.6yrs) male subjects took part in four, 30 min experimental interventions (aerobic AE, resistance RE, combined aerobic/resistance exercise CARE or no-exercise), in random order. Blood samples were collected and the measurement of brachial artery diameter by ultrasound was performed before, immediately after, and one hour after each intervention. Platelet activation was determined by the positive binding of antibodies to surface receptors exposed on activated platelets (anti-CD62P and PAC-1). RESULTS: Brachial artery diameter increased immediately following all three exercise modalities (P<0.001), and remained above pre-exercise levels 1hr post-RE and -CARE. No changes were observed in markers of in vivo platelet activation with any experimental protocol. CONCLUSION: These data suggest that post-exercise enhancement in arterial function may mitigate the acute impact of exercise on platelet activation.

Item Type: Article
Additional Information: Haynes, Andrew; Linden, Matthew D; Robey, Elisa; Watts, Gerald F; Barrett, P Hugh R; Naylor, Louise H; Green, Daniel J. Acute Impact of Different Exercise Modalities on Arterial and Platelet Function. Medicine & Science in Sports & Exercise. http://dx.doi.org/10.1249/MSS.0000000000001505
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Lippincott, Williams & Wilkins/American College of Sports Medicine
Related URLs:
Date Deposited: 21 Dec 2017 09:48
Last Modified: 15 Sep 2018 05:27
DOI or Identification number: 10.1249/MSS.0000000000001505
URI: http://researchonline.ljmu.ac.uk/id/eprint/7744

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