Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Genetic diversity of the African malaria vector Anopheles gambiae

Wilding, CS (2017) Genetic diversity of the African malaria vector Anopheles gambiae. Nature, 552. pp. 96-100. ISSN 0028-0836

[img] Text
1000g Final version.pdf - Accepted Version
Restricted to Repository staff only until 29 May 2018.

Download (2MB)

Abstract

The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes, which transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, here we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, and identified over 50 million single nucleotide polymorphisms within the accessible genome. These data revealed complex population structure and patterns of gene flow, with evidence of ancient expansions, recent bottlenecks, and local variation in effective population size. Strong signals of recent selection were observed in insecticide-resistance genes, with several sweeps spreading over large geographical distances and between species. The design of new tools for mosquito control using gene-drive systems will need to take account of high levels of genetic diversity in natural mosquito populations.

Item Type: Article
Uncontrolled Keywords: MD Multidisciplinary
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology > QR180 Immunology
R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Divisions: Natural Sciences and Psychology
Publisher: Nature Publishing Group
Related URLs:
Date Deposited: 05 Jan 2018 09:35
Last Modified: 05 Jan 2018 09:35
DOI or Identification number: 10.1038/nature24995
URI: http://researchonline.ljmu.ac.uk/id/eprint/7775

Actions (login required)

View Item View Item