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The recency ratio as predictor of early MCI

Bruno, D, Koscik, R, Woodard, J, Pomara, N and Johnson, S The recency ratio as predictor of early MCI. International Psychogeriatrics. ISSN 1741-203X (Accepted)

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Abstract

Objectives: Individuals with Alzheimer’s disease (AD) present poor immediate primacy recall accompanied by intact or exaggerated recency, which then tends to decline after a delay. Bruno et al. (2016) have shown that higher ratio scores between immediate and delayed recency (i.e., the recency ratio; Rr) are associated with cognitive decline in high-functioning older individuals. We tested whether Rr predicted conversion to early mild cognitive impairment (early MCI) from a cognitively healthy baseline.
Design: Data were analysed longitudinally with binomial regression. Baseline scores were used to predict conversion to early MCI after approximately 9 years.
Setting: Data were collected at the Wisconsin Registry of Alzheimer’s Prevention (WRAP), in Madison, Wisconsin.
Participants: For the study, 427 individuals were included in the analysis; all participants were 50 years of age or older and cognitively intact at baseline, and were native English speakers.
Measurements: Memory data were collected using the Rey’s Auditory Verbal Learning Test, and the early MCI diagnosis was obtained via consensus conference.
Results: Our results showed that higher Rr scores are correlated with greater risk of later early MCI diagnosis, and this association is independent of total recall performance.
Conclusions: Rr is an emerging cognitive marker of cognitive decline.

Item Type: Article
Uncontrolled Keywords: 17 Psychology And Cognitive Sciences, 11 Medical And Health Sciences
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Natural Sciences and Psychology
Publisher: Cambridge University Press (CUP)
Date Deposited: 12 Mar 2018 10:32
Last Modified: 28 Mar 2018 09:03
URI: http://researchonline.ljmu.ac.uk/id/eprint/8254

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