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Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells

Basar, N and Oridupa, OA and Ritchie, KJ and Nahar, L and Osman, NMM and Stafford, A and Kushiev, H and Kan, A and Sarker, SD (2015) Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells. PHYTOTHERAPY RESEARCH, 29 (6). pp. 944-948. ISSN 0951-418X

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Abstract

Glycyrrhiza glabra L. (Fabaceae), commonly known as 'liquorice', is a well-known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, antiinflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and cardioprotective properties. While glycyrrhizin, a sweet-tasting triterpene saponin, is the principal bioactive compound, several bioactive flavonoids and isoflavonoids are also present in the roots of this plant. In the present study, the cytotoxicity of the methanol extracts of nine samples of the roots of G.-glabra, collected from various geographical origins, was assessed against immortal human keratinocyte (HaCaT), lung adenocarcinoma (A549) and liver carcinoma (HepG2) cell lines using the in vitro 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide cell toxicity/viability assay. Considerable variations in levels of cytotoxicity were observed among various samples of G.-glabra.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Basar, N, Oridupa, OA, Ritchie, KJ, Nahar, L, Osman, NMM, Stafford, A, Kushiev, H, Kan, A, and Sarker, SD (2015), Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells. Phytother. Res., 29, 944–948, which has been published in final form at http://dx.doi.org/10.1002/ptr.5329 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Uncontrolled Keywords: 11 Medical And Health Sciences, 03 Chemical Sciences, 06 Biological Sciences
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
Divisions: Pharmacy & Biomolecular Sciences
Publisher: WILEY-BLACKWELL
Related URLs:
Date Deposited: 09 Oct 2015 12:06
Last Modified: 16 Mar 2016 00:50
DOI or Identification number: 10.1002/ptr.5329
URI: http://researchonline.ljmu.ac.uk/id/eprint/830

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