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Widespread Treponema pallidum Infection in Nonhuman Primates, Tanzania

Chuma, IS, Batamuzi, EK, Collins, DA, Fyumagwa, RD, Hallmaier-Wacker, LK, Kazwala, RR, Keyyu, JD, Lejora, IA, Lipende, IF, Lüert, S, Paciência, FMD, Piel, AK, Stewart, FA, Zinner, D, Roos, C and Knauf, S (2018) Widespread Treponema pallidum Infection in Nonhuman Primates, Tanzania. Emerging Infectious Diseases, 24 (6). ISSN 1080-6040

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Abstract

We investigated Treponema pallidum infection in 8 nonhuman primate species (289 animals) in Tanzania during 2015–2017. We used a serologic treponemal test to detect antibodies against the bacterium. Infection was further confirmed from tissue samples of skin-ulcerated animals by 3 independent PCRs (polA, tp47, and TP_0619). Our findings indicate that T. pallidum infection is geographically widespread in Tanzania and occurs in several species (olive baboons, yellow baboons, vervet monkeys, and blue monkeys). We found the bacterium at 11 of 14 investigated geographic locations. Anogenital ulceration was the most common clinical manifestation; orofacial lesions also were observed. Molecular data show that nonhuman primates in Tanzania are most likely infected with T. pallidum subsp. pertenue–like strains, which could have implications for human yaws eradication.

Item Type: Article
Uncontrolled Keywords: 1108 Medical Microbiology, 1117 Public Health And Health Services, 1103 Clinical Sciences
Subjects: Q Science > QL Zoology
Divisions: Natural Sciences and Psychology
Publisher: U.S. National Center for Infectious Diseases
Date Deposited: 22 May 2018 08:34
Last Modified: 22 May 2018 08:34
DOI or Identification number: 10.3201/eid2406.180037
URI: http://researchonline.ljmu.ac.uk/id/eprint/8367

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