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Can a low frequency Electrical Muscle Stimulation intervention improve endothelial function in Advanced Heart Failure Patients?

Ennis, S, McGregor, G, Shave, R, McDonnell, B, Thompson, A, Banerjee, P and Jones, H Can a low frequency Electrical Muscle Stimulation intervention improve endothelial function in Advanced Heart Failure Patients? ESC Heart Failure. ISSN 2055-5822 (Accepted)

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Abstract

Aim: Obtain initial estimates of the change in brachial artery endothelial function and maximal oxygen uptake (VO2peak) with 8-weeks of Low Frequency-Electrical Muscle Stimulation (LF-EMS) or sham in patients with advanced Chronic Heart Failure (CHF). Methods and Results: Using a double blind, randomised design, 35 patients with CHF (New York Heart Association class III-IV) were assigned to 8-weeks (5 x 60 mins per week) of either LF-EMS (4Hz, continuous) or sham (skin level stimulation only) of the quadriceps and hamstrings muscles. Four of the five sessions were at home and one under supervision. Ultrasound images of resting brachial artery diameter and post 5 min occlusion to determine flow-mediated dilation (FMD),a marker of vascular function and peak oxygen uptake (VO2peak) during cardiopulmonary exercise test, were measured before and after LF-EMS (n=20) and sham (n=15) interventions. FMD improved by 2.56% (95%CI: 0.69 to 3.80) with LF-EMS compared to sham (P=0.07). There were no notable changes in VO2 peak. Conclusion: Improvements in FMD with LF-EMS may have a clinically meaningful effect as higher FMD is associated with better prognosis. This is a preliminary finding and a larger trial is warranted.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Wiley
Date Deposited: 26 Apr 2018 10:36
Last Modified: 26 Apr 2018 10:36
URI: http://researchonline.ljmu.ac.uk/id/eprint/8581

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