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Whey Protein Augments Leucinemia and Post-Exercise p70S6K1 Activity Compared to a Hydrolysed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability

Impey, SG, Hammond, KM, Naughton, R, Langan-Evans, C, Shepherd, SO, Sharples, AP, Cegielski, J, Smith, K, Jeromson, S, Hamilton, DL, Close, GL and Morton, JP (2018) Whey Protein Augments Leucinemia and Post-Exercise p70S6K1 Activity Compared to a Hydrolysed Collagen Blend When in Recovery From Training With Low Carbohydrate Availability. International Journal of Sport Nutrition and Exercise Metabolism. ISSN 1526-484X

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Abstract

We examined the effects of whey versus collagen protein on skeletal muscle cell signalling responses associated with mitochondrial biogenesis and protein synthesis in recovery from an acute training session completed with low carbohydrate (CHO) availability. In a repeated measures design (after adhering to a 36-h exercise-dietary intervention to standardise pre-exercise muscle glycogen), eight males completed a 75-min non-exhaustive cycling protocol and consumed 22 g of a hydrolysed collagen blend (COLLAGEN) or whey (WHEY) protein 45 min prior to exercise, 22 g during exercise and 22 g immediately post-exercise. Exercise decreased (P<0.05) muscle glycogen content by comparable levels from pre-to post-exercise in both trials (≈ 300 to 150 mmol.kg-1 dw). WHEY protein induced greater increases in plasma BCAAs (P=0.03) and leucine (P=0.02) than COLLAGEN. Exercise induced (P<0.05) similar increases in PGC-1α (5-fold) mRNA at 1.5 h post-exercise between conditions though no affect of exercise (P>0.05) was observed for p53, Parkin and Beclin1 mRNA. Exercise suppressed (P<0.05) p70S6K1 activity in both conditions immediately post-exercise (≈ 25 fmol.min-1.mg-1). Post-exercise feeding increased p70S6K1 activity at 1.5 h post-exercise (P<0.05), the magnitude of which was greater (P <0.05) in WHEY (180 ± 105 fmol.min-1.mg-1) versus COLLAGEN (73 ± 42 fmol.min-1.mg-1). We conclude that protein composition does not modulate markers of mitochondrial biogenesis when in recovery from a training session deliberately completed with low CHO availability. In contrast, whey protein augments post-exercise p70S6K activity compared with hydrolysed collagen, as likely mediated via increased leucine availability.

Item Type: Article
Additional Information: This is the accepted version of the following article published in International Journal of Sport Nutrition and Exercise Metabolism available at: http://dx.doi.org/10.1123/ijsnem.2018-0054
Uncontrolled Keywords: 1106 Human Movement And Sports Science
Subjects: T Technology > TX Home economics > TX341 Nutrition. Foods and food supply
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Human Kinetics
Date Deposited: 16 May 2018 11:14
Last Modified: 19 Sep 2018 08:52
DOI or Identification number: 10.1123/ijsnem.2018-0054
URI: http://researchonline.ljmu.ac.uk/id/eprint/8680

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