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Insulin: Its role in the central control of reproduction

Sliwowska, JH, Fergani, C, Gawalek, M, Skowronska, B, Fichna, P and Lehman, MN (2014) Insulin: Its role in the central control of reproduction. Physiology and Behavior, 133. pp. 197-206. ISSN 1873-507X

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Abstract

Insulin has long been recognized as a key regulator of energy homeostasis via its actions at the level of the brain, but in addition, plays a role in regulating neural control of reproduction. In this review, we consider and compare evidence from animal models demonstrating a role for insulin for physiological control of reproduction by effects on GnRH/LH secretion. We also review the role that insulin plays in prenatal programming of adult reproduction, and consider specific candidate neurons in the adult hypothalamus by which insulin may act to regulate reproductive function. Finally, we review clinical evidence of the role that insulin may play in adult human fertility and reproductive disorders. Overall, while insulin appears to have a significant impact on reproductive neuroendocrine function, there are many unanswered questions regarding its precise sites and mechanisms of action, and their impact on developing and adult reproductive neuroendocrine function.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences, 11 Medical And Health Sciences, 17 Psychology And Cognitive Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Natural Sciences and Psychology
Publisher: Elsevier
Related URLs:
Date Deposited: 27 Jun 2018 09:09
Last Modified: 17 Sep 2018 18:47
DOI or Identification number: 10.1016/j.physbeh.2014.05.021
URI: http://researchonline.ljmu.ac.uk/id/eprint/8895

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