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Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA.

Dykes, IM and Emanueli, C (2017) Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA. Genomics Proteomics Bioinformatics, 15 (3). pp. 177-186. ISSN 1672-0229

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Abstract

Advances in genomics technology over recent years have led to the surprising discovery that the genome is far more pervasively transcribed than was previously appreciated. Much of the newly-discovered transcriptome appears to represent long non-coding RNA (lncRNA), a heterogeneous group of largely uncharacterised transcripts. Understanding the biological function of these molecules represents a major challenge and in this review we discuss some of the progress made to date. One major theme of lncRNA biology seems to be the existence of a network of interactions with microRNA (miRNA) pathways. lncRNA has been shown to act as both a source and an inhibitory regulator of miRNA. At the transcriptional level, a model is emerging whereby lncRNA bridges DNA and protein by binding to chromatin and serving as a scaffold for modifying protein complexes. Such a mechanism can bridge promoters to enhancers or enhancer-like non-coding genes by regulating chromatin looping, as well as conferring specificity on histone modifying complexes by directing them to specific loci.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences, 08 Information And Computing Sciences, 01 Mathematical Sciences
Subjects: Q Science > QH Natural history > QH426 Genetics
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Related URLs:
Date Deposited: 10 Jul 2018 08:28
Last Modified: 13 Oct 2018 16:25
DOI or Identification number: 10.1016/j.gpb.2016.12.005
URI: http://researchonline.ljmu.ac.uk/id/eprint/8934

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