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Carriers for the Targeted Delivery of Aerosolized Macromolecules for Pulmonary Pathologies.

Osman, N, Kaneko, K, Carini, V and Saleem, I (2018) Carriers for the Targeted Delivery of Aerosolized Macromolecules for Pulmonary Pathologies. Expert Opinion on Drug Delivery. ISSN 1744-7593

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Carriers_for_the_targeted_delivery_of_aerosolized_macromolecules_for_pulmonary_pathologies.pdf - Accepted Version
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Abstract

INTRODUCTION: Macromolecules with unique effects and potency are increasingly being considered for application in lung pathologies. Numerous delivery strategies for these macromolecules through the lung, have been investigated to improve the targeting and overall efficacy. Areas covered: Targeting approaches from delivery devices, formulation strategies and specific targets are discussed. Expert opinion: Although macromolecules are a heterogeneous group of molecules, a number of strategies have been investigated at the macro, micro and nanoscopic scale for the delivery of macromolecules to specific sites and cells of lung tissues. Targeted approaches are already in use at the macroscopic scale through inhalation devices and formulations, but targeting strategies at the micro and nanoscopic scale are still in the laboratory stage. The combination of controlling lung deposition and targeting after deposition, through a combination of targeting strategies could be the future direction for the treatment of lung pathologies through the pulmonary route.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis Group in Expert Opinion on Drug Delivery on 18/07/2018, available online: https://doi.org/10.1080/17425247.2018.1502267
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
Related URLs:
Date Deposited: 25 Jul 2018 12:24
Last Modified: 14 Sep 2018 20:38
DOI or Identification number: 10.1080/17425247.2018.1502267
URI: http://researchonline.ljmu.ac.uk/id/eprint/9015

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