Tools
Tools
Sirichaiwetchakoon, K, Lowe, GM, Thumanu, K and Eumkeb, G (2018) The Effect of Pluchea indica (L.) Less. Tea on Adipogenesis in 3T3-L1 Adipocytes and Lipase Activity. Evidence-Based Complementary and Alternative Medicine. ISSN 1741-427X
|
Text
The Effect of Pluchea indica (L.) Less. Tea on Adipogenesis in 3T3-L1 Adipocytes and Lipase Activity.pdf - Published Version Available under License Creative Commons Attribution. Download (9MB) | Preview |
Abstract
Obesity and hyperlipidemia are a major problem in the world. Pluchea indica (L.) Less. tea (PIT) is a beverage that has various indications. This study focused on the effect of the PIT on inhibiting adipogenesis of 3T3-L1 cells and pancreatic lipase enzyme activity. The viability of 3T3-L1 cells was not significantly decreased after exposure to 200 to 1000 μg mL−1 PIT compared to controls (p < 0.05). The PIT at 750 to 1000 μg mL−1 exhibited a significantly reduced lipid accumulation compared to the control (p < 0.05). The inhibitory effects of the PIT at 250 to 1000 μg mL−1 on lipase activity were significantly increased compared to control (p < 0.05). The FTIR results showed that the integrated areas of lipids, proteins, nucleic acids, glycogen, and carbohydrates of the PIT-treated 3T3-L1 adipocytes were significantly lower than the untreated 3T3-L1 adipocytes (p < 0.05). These findings may indicate that the PIT is not only capable of inhibiting lipids and carbohydrate accumulation in adipocytes but also has a potential to inhibit pancreatic lipase activity. So, the PIT may be further developed to the novel lipid-lowering herbal supplement for the management of overweight or obesity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 1104 Complementary And Alternative Medicine |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Pharmacy & Biomolecular Sciences |
| Publisher: | Hindawi Publishing Corporation |
| Related URLs: | |
| Date Deposited: | 15 Aug 2018 09:14 |
| Last Modified: | 04 Sep 2021 10:13 |
| DOI or ID number: | 10.1155/2018/4108787 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/9096 |
 |
View Item |