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Purpurogallin-A heme binding component of oak galls

Mehan, A, Migaz, N, Parikh, N, Truong, HV, Lambert, DJ, Messham, SJ, McKay, J, Mahamed, N, Brooks, SJ, Lloyd, M, Morris, H, Dempster, NM, Randle, LE, Burrell, HE, Sarker, SD, Nahar, L, Evans, PG, Dascombe, MJ, Strashnov, N, Edwards, G , Drew, MGB, Barran, P and Ismail, FMD (2015) Purpurogallin-A heme binding component of oak galls. In: BMSS Annual Meeting: Birmingham, 15 September 2015 - 17 September 2015, University of Birmingham – Edgbaston.

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Abstract

Recently, it has been shown that Purpurogallin (PPG), an orange benztropolone constituent of oak galls and its derivative, CU-CPT22, can compete with the binding of the specific lipoprotein ligand to toll-like receptors (TLRs), which are type I transmembrane proteins. These recognize pathogen-derived macromolecules that play a key role in the innate immune system. This system provides an attractive target for the treatment of various immune disorders. Notably, PPG also interacts with various metals and its mode of action against HIV in vitro may involve inhibition of metal containing integrases. In the current study, an optimised synthesis of PPG is presented together with its gas phase behaviour (probed by mass spectrometry) as well as its redox behaviour with porphyrins such as heme. This interaction may also explain its effects at metal containing integrases within HIV in vitro as well as its action during processing of iron complexes within Plasmodia. This compound could serve as a novel prototype for the synthesis of novel redox active antimalarials.

Item Type: Conference or Workshop Item (Poster)
Uncontrolled Keywords: hemin; purpurogallin; anticancer
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: BMSS
Date Deposited: 08 Nov 2018 09:31
Last Modified: 08 Nov 2018 09:31
URI: http://researchonline.ljmu.ac.uk/id/eprint/9135

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