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(Pyrazolyl)pyridine ruthenium(III) complexes: Synthesis, kinetics of substitution reactions with thiourea and biological studies

Omondi, RO, Ojwach, SO, Jaganyi, D and Fatokun, AA (2018) (Pyrazolyl)pyridine ruthenium(III) complexes: Synthesis, kinetics of substitution reactions with thiourea and biological studies. INORGANIC CHEMISTRY COMMUNICATIONS, 94. pp. 98-103. ISSN 1387-7003

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Abstract

Reactions of 2-bromo-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine (L1), 2,6-di (1H-pyrazol-1-yl) pyridine (L2) and 2,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)pyridine (L3) with RuCl3·3H2O led to the formation of their respective metal complexes [RuCl3(L1)] (1), [RuCl3(L2)] (2) and [RuCl3(L3)] (3). Solid state structure of complex 3 established the formation of a six-coordinate mononuclear compound in which L3 is tridentately bound. The order of reactivity of the studied complexes with thiourea (TU) nucleophile is in the form 1?>?2?>?3, in line with density functional theory (DFT) studies. The complexes displayed minimal cytotoxic activity against the HeLa cell line, consistent with molecular docking experiments which showed weaker DNA binding affinities.

Item Type: Article
Uncontrolled Keywords: 0302 Inorganic Chemistry, 0399 Other Chemical Sciences
Subjects: Q Science > QD Chemistry
Divisions: Pharmacy & Biomolecular Sciences
Publisher: ELSEVIER SCIENCE BV
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Date Deposited: 11 Sep 2018 10:33
Last Modified: 14 Sep 2018 16:47
DOI or Identification number: 10.1016/j.inoche.2018.06.006
URI: http://researchonline.ljmu.ac.uk/id/eprint/9199

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