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Resolving the True Ventricular Mural Architecture.

Stephenson, RS, Agger, P, Omann, C, Sanchez-Quintana, D, Jarvis, JC and Anderson, RH (2018) Resolving the True Ventricular Mural Architecture. Journal of Cardiovascular Development and Disease, 5 (2). ISSN 2308-3425

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Abstract

The precise nature of packing together of the cardiomyocytes within the ventricular walls has still to be determined. The spiraling nature of the chains of interconnected cardiomyocytes has long been recognized. As long ago as the end of the nineteenth century, Pettigrew had emphasized that the ventricular cone was not arranged on the basis of skeletal muscle. Despite this guidance, subsequent anatomists described entities such as “bulbo-spiral muscles”, with this notion of subunits culminating in the suggestion that the ventricular cone could be unwrapped so as to produce a “ventricular myocardial band”. Others, in contrast, had suggested that the ventricular walls were arranged on the basis of “sheets”, or more recently “sheetlets”, with investigators seeking to establishing the angulation of these entities using techniques such as magnetic resonance imaging. Our own investigations, in contrast, have shown that the cardiomyocytes are aggregated together within the supporting fibrous matrix so as to produce a three-dimensional myocardial mesh. In this review, we summarize the previous accounts, and provide the anatomical evidence we have thus far accumulated to support the model of the myocardial mesh. We show how these anatomic findings underscore the concept of the myocardial mesh functioning in antagonistic fashion. They lend evidence to support the notion that the ventricular myocardium works as a muscular hydrostat.

Item Type: Article
Uncontrolled Keywords: cardiac antagonism; cardiomyocytes; fibrous matrix; ventricular walls
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: MDPI
Related URLs:
Date Deposited: 27 Sep 2018 10:51
Last Modified: 28 Sep 2018 12:11
DOI or Identification number: 10.3390/jcdd5020034
URI: http://researchonline.ljmu.ac.uk/id/eprint/9343

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