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Cytokine responses to repeated, prolonged walking in lean versus overweight/obese individuals.

Verheggen, RJHM, Eijsvogels, TMH, Catoire, M, Terink, R, Ramakers, R, Bongers, CCWG, Mensink, M, Hermus, ARMM, Thijssen, DHJ and Hopman, MTE (2018) Cytokine responses to repeated, prolonged walking in lean versus overweight/obese individuals. Journal of Science and Medicine in Sport. ISSN 1878-1861

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Abstract

OBJECTIVES: Obesity is characterized by a pro-inflammatory state, which plays a role in the pathogenesis of metabolic and cardiovascular disease. An exercise bout causes a transient increase in pro-inflammatory cytokines, whilst training has anti-inflammatory effects. No previous study examined whether the exercise-induced increase in pro-inflammatory cytokines is altered with repeated prolonged exercise bouts and whether this response differs between lean and overweight/obese individuals. DESIGN: Lean (n=25, BMI 22.9±1.5kg/m2) and age-/sex-matched overweight/obese (n=25; BMI 27.9±2.4kg/m2) individuals performed walking exercise for 30, 40 or 50km per day on four consecutive days (distances similar between groups). METHODS: Circulating cytokines (IL-6, IL-10, TNF-α, IL-1β and IL-8) were examined at baseline and <30min after the finish of each exercise day. RESULTS: At baseline, no differences in circulating cytokines were present between groups. In response to prolonged exercise, all cytokines increased on day 1 (IL-1β: P=0.02; other cytokines: P<0.001). IL-6 remained significantly elevated during the 4 exercise days, when compared to baseline. IL-10, TNF-α, IL-1β and IL-8 returned to baseline values from exercise day 2 (IL-10, IL-1β, IL-8) or exercise day 3 (TNF-α) onward. No significant differences were found between groups for all cytokines, except IL-8 (Time*Group Interaction P=0.02). CONCLUSIONS: These data suggest the presence of early adaptive mechanisms in response to repeated prolonged walking, demonstrated by attenuated exercise-induced elevations in cytokines on consecutive days that occur similar in lean and overweight/obese individuals.

Item Type: Article
Uncontrolled Keywords: 1106 Human Movement And Sports Science, 1117 Public Health And Health Services
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Elsevier
Related URLs:
Date Deposited: 28 Sep 2018 08:38
Last Modified: 28 Sep 2018 12:11
DOI or Identification number: 10.1016/j.jsams.2018.07.019
URI: http://researchonline.ljmu.ac.uk/id/eprint/9354

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