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Novel applications of flow cytometry to assess whole murine skeletal muscle and myonuclei number responses to atrophy and recovery.

Viggars, M (2018) Novel applications of flow cytometry to assess whole murine skeletal muscle and myonuclei number responses to atrophy and recovery. Doctoral thesis, Liverpool John Moores University.

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Abstract

This thesis will present an introduction to cellular and molecular adaptation to loading and unloading of skeletal muscle, whilst exploring the advantages and disadvantages of current techniques employed in the field of exercise biochemistry. In response to the current techniques used to assess the signal transduction and protein changes present in response to loading and unloading, we propose a potential, novel method of assessing whole, murine skeletal muscle protein isoforms via flow cytometry. In addition to this, this thesis also explores the changes in morphology and myonuclear number within skeletal muscle following varying periods of atrophy, and recovery from atrophy produced in response to tetrodotoxin administration to silence a motor nerve and therefore muscular contraction in the ankle dorsiflexor muscles of the rat hindlimb.

Item Type: Thesis (Doctoral)
Uncontrolled Keywords: Flow Cytometry; Skeletal Muscle; Atrophy; Myonuclear Domain
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Date Deposited: 01 Oct 2018 09:29
Last Modified: 01 Oct 2018 09:29
DOI or Identification number: 10.24377/researchonline.ljmu.ac.uk.00009368
Supervisors: Jarvis, J
URI: http://researchonline.ljmu.ac.uk/id/eprint/9368

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