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Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis.

Cirer-Sastre, R, Legaz-Arrese, A, Corbi, F, George, KP, Nie, J, Carranza-García, LE and Reverter-Masià, J (2018) Cardiac Biomarker Release After Exercise in Healthy Children and Adolescents: A Systematic Review and Meta-Analysis. Pediatric Exercise Science. ISSN 1543-2920

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Abstract

PURPOSE: The authors evaluated the impact of acute exercise and 24-hour recovery on serum concentration of cardiac troponins T and I (cTnT and cTnI) and N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP) in healthy children and adolescents. The authors also determined the proportion of participants exceeding the upper reference limits and acute myocardial infarction cutoff for each assay. METHOD: Web of Science, SPORTDiscus, MEDLINE, ScienceDirect, and Scopus databases were systematically searched up to November 2017. Studies were screened and quality-assessed; the data was systematically extracted and analyzed. RESULTS: From 751 studies initially identified, 14 met the inclusion criteria for data extraction. All 3 biomarkers were increased significantly after exercise. A decrease from postexercise to 24 hours was noted in cTnT and cTnI, although this decrease was only statistically significant for cTnT. The upper reference limit was exceeded by 76% of participants for cTnT, a 51% for cTnI, and a 13% for NT-proBNP. Furthermore, the cutoff value for acute myocardial infarction was exceeded by 39% for cTnT and a 11% for cTnI. Postexercise peak values of cTnT were associated with duration and intensity (Q(3) = 28.3, P < .001) while NT-proBNP peak values were associated with duration (Q(2) = 11.9, P = .003). CONCLUSION: Exercise results in the appearance of elevated levels of cTnT, cTnI, and NT-proBNP in children and adolescents. Postexercise elevations of cTnT and NT-proBNP are associated with exercise duration and intensity.

Item Type: Article
Additional Information: Accepted author manuscript version reprinted, by permission, from Pediatric Exercise Science, 2018, https://doi.org/10.1123/pes.2018-0058. © Human Kinetics, Inc.
Uncontrolled Keywords: 1106 Human Movement And Sports Science, 1114 Paediatrics And Reproductive Medicine, 1302 Curriculum And Pedagogy
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Human Kinetics
Related URLs:
Date Deposited: 07 Nov 2018 09:29
Last Modified: 07 Nov 2018 13:41
DOI or Identification number: 10.1123/pes.2018-0058
URI: http://researchonline.ljmu.ac.uk/id/eprint/9464

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