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Hit Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People with Type 1 Diabetes.

Scott, SN, Cocks, MS, Andrews, RC, Narendran, P, Purewal, TS, Cuthbertson, DJ, Wagenmakers, AJM and Shepherd, SO (2018) Hit Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People with Type 1 Diabetes. Journal of Clinical Endocrinology & Metabolism. ISSN 0021-972X

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Abstract

AIMS: To investigate whether 1) six weeks of high-intensity interval training (HIT) induces similar improvements in cardio-metabolic health markers as moderate-intensity continuous training (MICT) in people with type 1 diabetes, and 2) whether HIT abolishes acute reductions in plasma glucose observed following MICT sessions. METHODS: Fourteen sedentary individuals with type 1 diabetes (n=7 per group) completed six weeks of HIT or MICT 3 times per week. Pre- and post-training measurements were made of 24h interstitial glucose profiles (using continuous glucose monitors (CGMS)) and cardio-metabolic health markers (V˙O2peak, blood lipid profile and aortic pulse wave velocity; aPWV). Capillary blood glucose concentrations were assessed before and after exercise sessions throughout the training programme to investigate changes in blood glucose during exercise in the fed state. RESULTS: Six weeks of HIT or MICT increased V˙O2peak by 14% and 15%, respectively (P<0.001), and aPWV by 12% (P<0.001), with no difference between groups. 24h CGMS data revealed no differences in incidence or percentage of time spent in hypoglycaemia following training in either group (P>0.05). In the fed state, the mean change in capillary blood glucose concentration during the HIT sessions was -0.2±0.5 mmol/L, whereas blood glucose change was -5.5±0.4 mmol/L during MICT. CONCLUSIONS: Six weeks of HIT improved V˙O2peak and aortic PWV to a similar extent as MICT. The finding that blood glucose remained stable during HIT in the fed state, but consistently fell during MICT, suggests that HIT may be the preferred training mode for some people with type 1 diabetes.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Clinical Endocrinology & Metabolism following peer review. The version of record Sam N Scott, Matt Cocks, Rob C Andrews, Parth Narendran, Tejpal S Purewal, Daniel J Cuthbertson, Anton J M Wagenmakers, Sam O Shepherd; Hit Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People with Type 1 Diabetes, The Journal of Clinical Endocrinology & Metabolism is available online at: http://dx.doi.org/10.1210/jc.2018-01309
Uncontrolled Keywords: 1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Oxford University Press (OUP)
Related URLs:
Date Deposited: 11 Oct 2018 09:50
Last Modified: 11 Oct 2018 09:50
DOI or Identification number: 10.1210/jc.2018-01309
URI: http://researchonline.ljmu.ac.uk/id/eprint/9469

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