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Embracing the polypill as a cardiovascular therapeutic: is this the best strategy?

Franczyk, B, Gluba-Brzózka, A, Jurkiewicz, Ł, Penson, P, Banach, M and Rysz, J (2018) Embracing the polypill as a cardiovascular therapeutic: is this the best strategy? Expert Opinion on Pharmacotherapy. ISSN 1465-6566

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Abstract

INTRODUCTION: Cardiovascular disease (CVD) is an important cause of mortality and morbidity worldwide. CVD morbidity and mortality are associated with significant financial costs related to hospitalization, medication, and lost productivity. The concept of the 'polypill' for the reduction of cardiovascular risk was proposed in 2000. A polypill is a fixed combination of drugs in a single tablet or capsule. The initial polypill consisted of three different classes of antihypertensive drugs (each at half dose), in addition to aspirin, a statin, and folic acid. The challenge today is to produce polypills containing drugs with established efficacy and complementary actions. Areas covered: The authors provide their expert perspectives on the polypill and consider the randomized clinical trials that have evaluated the safety, efficacy, adherence, and cost-effectiveness of polypills. Expert opinion: The polypill makes prescribing easier by reducing the need for complex treatment algorithms and dose titration. It also appears to be cost-effective. However, there are several issues that need to be addressed before the polypill can be used routinely. A single polypill formulation may not be suitable for all patients. It may be necessary to develop several types of polypill to meet the needs of different patient groups.

Item Type: Article
Additional Information: This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Pharmacotherapy on 08/10/18, available online: http://www.tandfonline.com/10.1080/14656566.2018.1532501
Uncontrolled Keywords: 1115 Pharmacology And Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Taylor & Francis
Related URLs:
Date Deposited: 09 Nov 2018 10:36
Last Modified: 09 Nov 2018 10:37
DOI or Identification number: 10.1080/14656566.2018.1532501
URI: http://researchonline.ljmu.ac.uk/id/eprint/9631

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