Bacellar, IOL, Baptista, MS, Junqueira, HC, Wainwright, M, Thalmann, F, Marques, CM and Schroder, AP (2018) Permeability of DOPC bilayers under photoinduced oxidation: Sensitivity to photosensitizer. Biochimica et Biophysica Acta (BBA) Biomembranes, 1860 (11). pp. 2366-2373. ISSN 0005-2736

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Abstract

The modification of lipid bilayer permeability is one of the most striking yet poorly understood physical transformations that follow photoinduced lipid oxidation. We have recently proposed that the increase of permeability of photooxidized 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayers is controlled by the time required by the oxidized lipid species to diffuse and aggregate into pores. Here we further probe this mechanism by studying photosensitization of DOPC membranes by methylene blue (MB) and DO15, a more hydrophobic phenothiazinium photosensitizer, under different irradiation powers. Our results not only reveal the interplay between the production rate and the diffusion of the oxidized lipids, but highlight also the importance of photosensitizer localization in the kinetics of oxidized membrane permeability.

Item Type:	Article
Uncontrolled Keywords:	0601 Biochemistry And Cell Biology, 0904 Chemical Engineering
Subjects:	Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy & Biomolecular Sciences
Publisher:	Elsevier
Related URLs:	Author
Date Deposited:	15 Nov 2018 09:25
Last Modified:	04 Sep 2021 09:56
DOI or ID number:	10.1016/j.bbamem.2018.06.001
URI:	https://researchonline.ljmu.ac.uk/id/eprint/9651

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