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MicroRNA-184 and its lncRNA sponge uca1 are induced in wounded keratinocytes in a store-operated calcium entry-dependent manner.

Richardson, A, Owens, DJ and Ross, K (2018) MicroRNA-184 and its lncRNA sponge uca1 are induced in wounded keratinocytes in a store-operated calcium entry-dependent manner. British Journal of Dermatology. ISSN 1365-2133

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Abstract

There remains a significant need for therapeutic interventions for wound healing as the clinical and socioeconomic challenges presented by the ageing population and associated rise in non-healing wounds persist, exerting enormous pressure on health services. MicroRNAs (miRNAs) are short ≈22 nucleotide non-coding RNA molecules that fine-tune gene expression by degradation of mRNA targets. Several miRNAs promote keratinocyte migration, including miR-21, miR-31 and miR-132 (reviewed in 3 ), hence miRNA-dependent migration is emerging as a framework for wound healing. This article is protected by copyright. All rights reserved.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Richardson, A. , Owens, D. and Ross, K. (2019), MicroRNA‐184 and its lncRNA sponge UCA1 are induced in wounded keratinocytes in a store‐operated calcium entry‐dependent manner. Br J Dermatol. Accepted Author Manuscript. doi:10.1111/bjd.17576, which has been published in final form at http://dx.doi.org/10.1111/bjd.17576. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Uncontrolled Keywords: 1103 Clinical Sciences, 1112 Oncology and Carcinogenesis
Subjects: Q Science > QR Microbiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Sport & Exercise Sciences
Publisher: Wiley
Related URLs:
Date Deposited: 15 Jan 2019 08:38
Last Modified: 15 Jan 2019 08:48
DOI or Identification number: 10.1111/bjd.17576
URI: http://researchonline.ljmu.ac.uk/id/eprint/9937

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