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Epigenetic modifications during exercise

Goldberg, ND, Astratenkova, IV, Akhmetov, I and Rogozkin, VA (2018) Epigenetic modifications during exercise. Teoriya i Praktika Fizicheskoy Kultury, 2. pp. 51-55. ISSN 0040-3601

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Abstract

Mapping on the human genome and genome of other organisms revealed not only the DNA organization principles, but also showed the regulation complexity of the structural and metabolic genes expression. It turned out that external influences such as nutrition, stress, physical activity and other external stimuli change genes expression and control it through a complex set of regulatory mechanisms. A complex set of molecular mechanisms, including genetic and epigenetic factors, is involved in the regulation of skeletal muscle metabolism. Epigenetic regulation of gene expression in human skeletal muscles is carried out at three levels: DNA methylation, histone modification and mRNA-microRNA interaction. The article considers the possible mechanisms of epigenetic regulation of intracellular metabolism of skeletal muscles during single and systematic exercises. © 2018 Teoriya i praktika fizicheskoy kul'tury i sporta. All rights reserved.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Teoriya
Date Deposited: 17 Jan 2019 12:13
Last Modified: 17 Jan 2019 12:17
URI: http://researchonline.ljmu.ac.uk/id/eprint/9964

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