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Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments

Pandamooz, S, Jurek, B, Meinung, C-P, Baharvand, Z, Shahem-abadi, AS, Haerteis, S, Miyan, JA, Downing, J, Dianatpour, M, Borhani-Haghighi, A and Salehi, MS (2022) Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments. Annual Review of Pharmacology and Toxicology, 62 (1). pp. 25-53. ISSN 0362-1642

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Abstract

In December 2019, a novel coronavirus crossed species barriers to infect humans and was effectively transmitted from person to person, leading to a worldwide pandemic. Development of effective clinical interventions, including vaccines and antiviral drugs that could prevent or limit the burden or transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health priority. It is thus of utmost importance to assess possible therapeutic strategies against SARS-CoV-2 using experimental models that recapitulate aspects of the human disease. Here, we review available models currently being developed and used to study SARS-CoV-2 infection and highlight their application to screen potential therapeutic approaches, including repurposed antiviral drugs and vaccines. Each identified model provides a valuable insight into SARS-CoV-2 cellular tropism, replication kinetics, and cell damage that could ultimately enhance understanding of SARS-CoV-2 pathogenesis and protective immunity.

Item Type: Article
Uncontrolled Keywords: 06 Biological Sciences, 11 Medical and Health Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Annual Reviews
Date Deposited: 09 Feb 2022 11:22
Last Modified: 09 Feb 2022 11:30
DOI or Identification number: 10.1146/annurev-pharmtox-121120-012309
URI: https://researchonline.ljmu.ac.uk/id/eprint/14584

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