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Physical Activity and Sedentary Time: Association with Metabolic Health and Liver Fat.

Bowden Davies, KA, Sprung, VS, Norman, JA, Thompson, A, Mitchell, KL, Harrold, JA, Finlayson, G, Gibbons, C, Wilding, JPH, Kemp, GJ, Hamer, M and Cuthbertson, DJ (2019) Physical Activity and Sedentary Time: Association with Metabolic Health and Liver Fat. Medicine & Science in Sports & Exercise. ISSN 0195-9131

Physical activity and sedentary time association with metabolic health and liver fat.pdf - Accepted Version

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INTRODUCTION/PURPOSE: To investigate whether a) lower levels of daily physical activity (PA) and greater sedentary time accounted for contrasting metabolic phenotypes (higher liver fat/presence of metabolic syndrome [MetS+] vs lower liver fat/absence of metabolic syndrome [MetS-]) in individuals of similar BMI and b) the association of sedentary time on metabolic health and liver fat. METHODS: Ninety-eight habitually active participants (53 female, 45 male; age 39±13 years; BMI 26.9±5.1 kg/m), underwent assessments of PA (SenseWear armband; wear time ~98%), cardio-respiratory fitness (V[Combining Dot Above]O2 peak), body composition (MRI and MRS) and multi-organ insulin sensitivity (OGTT). We undertook a) cross-sectional analysis comparing four groups: non-obese or obese, with and without metabolic syndrome (MetS+ vs MetS-) and b) univariate and multivariate regression for sedentary time and other levels of PA in relation to liver fat. RESULTS: Light, moderate and vigorous PA did not account for differences in metabolic health between individuals, whether non-obese or obese, although MetS+ individuals were more sedentary, with a higher number, and prolonged bouts (~1-2 hours). Overall, sedentary time, average daily METS and V[Combining Dot Above]O2 peak were each independently associated with liver fat percentage. Each additional hour of daily sedentary time was associated with a 1.15% (95% CI, 1.14-1.50%) higher liver fat content. CONCLUSIONS: Greater sedentary time, independent of other levels of PA, is associated with being metabolically unhealthy; even in habitually active people, lesser sedentary time, and higher cardio-respiratory fitness and average daily METS is associated with lower liver fat.This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Item Type: Article
Additional Information: This is the peer reviewed version, which has been published in final form at http://dx.doi.org/10.1249/MSS.0000000000001901
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American College of Sports Medicine
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Date Deposited: 02 Apr 2019 10:58
Last Modified: 04 Sep 2021 09:32
DOI or ID number: 10.1249/MSS.0000000000001901
URI: https://researchonline.ljmu.ac.uk/id/eprint/10476
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