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Statin-induced nitric oxide signalling: mechanisms and therapeutic implications

Gorabi, AM, Kiaie, N, Hajighasemi, S, Banach, M, Penson, P, Jamialahmadi, T and Sahebkar, A (2019) Statin-induced nitric oxide signalling: mechanisms and therapeutic implications. Journal of Clinical Medicine, 8 (12). ISSN 2077-0383

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Open Access URL: https://doi.org/10.3390/jcm8122051 (Published version)


In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed.

Item Type: Article
Uncontrolled Keywords: 1103 Clinical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: MDPI AG
Date Deposited: 25 Nov 2019 12:04
Last Modified: 03 Sep 2021 22:57
DOI or ID number: 10.3390/jcm8122051
URI: https://researchonline.ljmu.ac.uk/id/eprint/11818
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