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Insulin resistance in the offspring of parents with type 2 diabetes

Wagenmakers, AJM (2005) Insulin resistance in the offspring of parents with type 2 diabetes. PLoS Medicine, 2 (9). ISSN 1549-1676

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The global epidemic of type 2 diabetes is a pressing public health concern associated with a rapidly growing socioeconomic burden. Insulin resistance (IR) is an early event in the pathogenesis of type 2 diabetes. IR is characterised by a reduced ability of insulin to stimulate glucose uptake in skeletal muscle and by hyperglycaemia (high blood glucose concentration), at first only in periods following meal ingestion but later also in the overnight-fasted state.
In patients with type 2 diabetes, IR is progressive and after several years often leads to the development of secondary diabetes symptoms (including hypertriglyceridaemia, obesity, and pathology of the macro- and microvasculature). Eventually (after more than ten years) severe medical complications may develop, including retinopathy, neuropathy, tissue necrosis in the extremities, renal failure, and cardiomyopathy.
A progressive reduction over the last few decades of daily engagement in physically demanding activities and the recent growth in unbalanced diets are generally considered to be the primary causes of the dramatic rise in type 2 diabetes [1]. A genetic predisposition also runs in families and populations. In this month's PLoS Medicine, Kitt Petersen and colleagues [2] report new information on the early events in the underlying pathogenic mechanism that leads to the development of IR.

Item Type: Article
Uncontrolled Keywords: 11 Medical and Health Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Sport & Exercise Sciences
Publisher: Public Library of Science
Related URLs:
Date Deposited: 17 Feb 2020 11:53
Last Modified: 04 Sep 2021 07:53
DOI or ID number: 10.1371/journal.pmed.0020289
URI: https://researchonline.ljmu.ac.uk/id/eprint/12261
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