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Biochanin A: A Novel Bioactive Multifunctional Compound from Nature

Sarfraz, A, Javeed, M, Shah, MA, Hussain, G, Shafiq, N, Sarfraz, I, Riaz, A, Sadiqa, A, Zara, R, Zafar, S, Kanwal, L, Sarker, SD and Rasul, A (2020) Biochanin A: A Novel Bioactive Multifunctional Compound from Nature. Science of the Total Environment, 722. ISSN 0048-9697

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Natural products (NPs) will continue to serve humans as matchless source of novel drug leads and inspiration for the synthesis of non-natural drugs. As our scientific understanding of 'nature' is rapidly expanding, it would be worthwhile to illuminate the pharmacological distinctions of NPs to the scientific community and public. Flavonoids have long fascinated scientists with their remarkable structural diversity as well as biological functions. Consequently, this review aims to shed light on the sources and pharmacological significance of a dietary isoflavone, biochanin A, which has been recently emerged as multitargeted and multifunctional guardian of human health. Biochanin A possesses anti-inflammatory, anticancer, neuroprotective, antioxidant, anti-microbial, and hepatoprotective properties. This anticancer isoflavone combat cancer development by inducing apoptosis, inhibition of metastasis and arresting cell cycle via targeting several deregulated signaling pathways of cancer. It fights inflammation by blocking the expression and activity of pro-inflammatory cytokines via modulation of NF-κB and MAPKs. Biochanin A acts as a neuroprotective agent by inhibiting microglial activation and apoptosis of neurons. As biochanin A has potential to modulate several biological networks, thus, we anticipate that this therapeutically potent compound might serve as novel lead for drug development in the near future.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Elsevier
Date Deposited: 13 Mar 2020 12:52
Last Modified: 13 Jan 2022 09:45
DOI or ID number: 10.1016/j.scitotenv.2020.137907
URI: https://researchonline.ljmu.ac.uk/id/eprint/12488
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