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Therapeutic potential pf phenylethanoid glycosides: A systematic review

Wu, L, Georgiev, MI, Cao, H, Nahar, L, El-Seedi, HR, Sarker, SD, Xiao, J and Lu, B (2020) Therapeutic potential pf phenylethanoid glycosides: A systematic review. Medicinal Research Reviews, 40 (6). pp. 2605-2649. ISSN 0198-6325

Therapeutic Potential of Phenylethanoid Glycoside A Systematic Review.pdf - Accepted Version

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Phenylethanoid glycosides (PhGs) are generally water-soluble phenolic compounds that occur in many medicinal plants. Until June 2020, more than 572 PhGs have been isolated and identified. PhGs possess antioxidant, neuroprotective, anti-inflammatory, antibacterial, antiviral, antidiabetic, anticancer, and antiobesity properties. Despite these promising benefits, PhGs have failed to fulfill their therapeutic applications due to their poor bioavailability. The attempts to understand their metabolic pathways to improve their bioavailability are investigated. In this review article, we will first summarize the number of PhGs compounds which is not accurate in the literature. The latest information on the biological activities, structure-activity relationships, mechanisms and especially the clinical applications of PhGs will be reviewed. The bioavailability of PhGs will be summarized and factors leading to the low bioavailability will be analyzed. Recent advances in methods such as bioenhancers and nanotechnology to improve the bioavailability of PhGs are also summarized. The existing scientific gaps of PhGs in knowledge are also discussed, highlighting research directions in the future.

Item Type: Article
Additional Information: his is the peer reviewed version of the following article: Wu, L, Georgiev, MI, Cao, H, et al. Therapeutic potential of phenylethanoid glycosides: A systematic review. Med Res Rev. 2020; 40: 2605- 2649, which has been published in final form at https://doi.org/10.1002/med.21717. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Uncontrolled Keywords: 0304 Medicinal and Biomolecular Chemistry, 0601 Biochemistry and Cell Biology, 1115 Pharmacology and Pharmaceutical Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Wiley
Date Deposited: 21 Jul 2020 08:46
Last Modified: 12 Jan 2022 10:45
DOI or ID number: 10.1002/med.21717
URI: https://researchonline.ljmu.ac.uk/id/eprint/13330
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