Alzheimer’s disease: Natural products as inhibitors of neuroinflammation

Olajide, OA and Sarker, SD (2020) Alzheimer’s disease: Natural products as inhibitors of neuroinflammation. Inflammopharmacology, 28. pp. 1439-1455. ISSN 0925-4692

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Abstract

Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD.

Item Type:	Article
Uncontrolled Keywords:	1115 Pharmacology and Pharmaceutical Sciences
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Pharmacy and Biomolecular Sciences
Publisher:	Springer Verlag
Date of acceptance:	28 August 2020
Date of first compliant Open Access:	11 January 2022
Date Deposited:	26 Aug 2020 14:55
Last Modified:	11 Jan 2022 16:30
DOI or ID number:	10.1007/s10787-020-00751-1
URI:	https://researchonline.ljmu.ac.uk/id/eprint/13552

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