Olajide, OA and Sarker, SD Alzheimer’s disease: Natural products as inhibitors of neuroinflammation. Inflammopharmacology. ISSN 0925-4692 (Accepted)
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Abstract
Alzheimer’s disease (AD) is the most common form of dementia and affects 44 million people worldwide. New emerging evidence from pre-clinical and clinical investigations shows that neuroinflammation is a major pathological component of AD suggesting that anti-inflammatory strategies are important in delaying the onset or slowing the progression of the disease. However, efforts to employ current anti-inflammatory agents in AD clinical trials have produced limited success. Consequently, there is a need to explore anti-inflammatory natural products, which target neuroinflammatory pathways relevant to AD pathogenesis. This review summarises important druggable molecular targets of neuroinflammation and presents classes of anti-neuroinflammatory natural products with potentials for preventing and reducing symptoms of AD.
Item Type: | Article |
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Uncontrolled Keywords: | 1115 Pharmacology and Pharmaceutical Sciences |
Subjects: | R Medicine > RM Therapeutics. Pharmacology |
Divisions: | Pharmacy & Biomolecular Sciences |
Publisher: | Springer Verlag |
Date Deposited: | 26 Aug 2020 14:55 |
Last Modified: | 26 Aug 2020 15:00 |
URI: | https://researchonline.ljmu.ac.uk/id/eprint/13552 |
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