Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Long-Term and Acute Benefits of Reduced Sitting on Vascular Flow and Function.

Hartman, YAW, Tillmans, LCM, Benschop, DL, Hermans, ANL, Nijssen, KMR, Eijsvogels, TMH, Willems, PHGM, Tack, CJ, Hopman, MTE, Claassen, JAHR and Thijssen, DHJ (2021) Long-Term and Acute Benefits of Reduced Sitting on Vascular Flow and Function. Medicine and Science in Sports and Exercise, 53 (2). pp. 341-350. ISSN 1530-0315

Hartman MSSE 2020.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial.

Download (2MB) | Preview


PURPOSE: Sedentary behavior increases the risk for cardiovascular and cerebrovascular disease. To understand potential benefits and underlying mechanisms, we examined the acute and long-term effect of reduced sitting intervention on vascular and cerebrovascular function. METHODS: This prospective study included 24 individuals with increased cardiovascular risk (65 ± 5 yr, 29.8 ± 3.9 kg·m-2). Before and after 16-wk reduced sitting, using a mobile health device with vibrotactile feedback, we examined (i) vascular function (flow-mediated dilation [FMD]), (ii) cerebral blood flow velocity (CBFv, transcranial Doppler), and (iii) cerebrovascular function (cerebral autoregulation [CA] and cerebral vasomotor reactivity [CVMR]). To better understand potential underlying mechanisms, before and after intervention, we evaluated the effects of 3 h sitting with and without light-intensity physical activity breaks (every 30 min). RESULTS: The first wave of participants showed no change in sedentary time (n = 9, 10.3 ± 0.5 to 10.2 ± 0.5 h·d-1, P = 0.87). Upon intervention optimization by participants' feedback, the subsequent participants (n = 15) decreased sedentary time (10.2 ± 0.4 to 9.2 ± 0.3 h·d-1, P < 0.01). This resulted in significant increases in FMD (3.1% ± 0.3% to 3.8% ± 0.4%, P = 0.02) and CBFv (48.4 ± 2.6 to 51.4. ±2.6 cm·s-1, P = 0.02), without altering CA or CVMR. Before and after the 16-wk intervention, 3-h exposure to uninterrupted sitting decreased FMD and CBFv, whereas physical activity breaks prevented a decrease (both P < 0.05). CA and CVMR did not change (P > 0.20). CONCLUSION: Long-term reduction in sedentary behavior improves peripheral vascular function and cerebral blood flow and acutely prevents impaired vascular function and decreased cerebral blood flow. These results highlight the potential benefits of reducing sedentary behavior to acutely and chronically improve cardio- or cerebrovascular risk.

Item Type: Article
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences, 1116 Medical Physiology, 1117 Public Health and Health Services
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: American College of Sports Medicine
Related URLs:
Date Deposited: 01 Feb 2021 11:01
Last Modified: 01 Feb 2022 00:50
DOI or ID number: 10.1249/MSS.0000000000002462
URI: https://researchonline.ljmu.ac.uk/id/eprint/14361
View Item View Item