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Hydration Marker Diagnostic Accuracy to Identify Mild Intracellular and Extracellular Dehydration

Owen, JA, Fortes, MB, Rahman, SU, Jibani, M, Walsh, NP and Oliver, SJ (2019) Hydration Marker Diagnostic Accuracy to Identify Mild Intracellular and Extracellular Dehydration. International Journal of Sport Nutrition & Exercise Metabolism, 29 (6). pp. 604-611. ISSN 1543-2742

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Abstract

Identifying mild dehydration (</=2% of body mass) is important to prevent the negative effects of more severe dehydration on human health and performance. It is unknown whether a single hydration marker can identify both mild intracellular and extracellular dehydration with adequate diagnostic accuracy (>/=0.7 receiver operating characteristic-area under the curve (ROC-AUC)). Thus, in 15 young healthy men, we determined the diagnostic accuracy of 15 hydration markers after three randomized 48-h trials; euhydration (EU, water 36 ml.kg.d(-1)), intracellular dehydration caused by exercise and 48 h of fluid restriction (ID, water 2 ml.kg.d(-1)), and extracellular dehydration caused by a 4 h diuretic-induced diuresis, begun at 44 h (ED, Furosemide 0.65 mg.kg(-1)). Body mass was maintained on EU and dehydration was mild on ID and ED (1.9 (0.5)% and 2.0 (0.3)% of body mass, respectively). Urine color, urine specific gravity, plasma osmolality, saliva flow rate, saliva osmolality, heart rate variability and dry mouth identified ID (ROC-AUC; range 0.70-0.99) and postural heart rate change identified ED (ROC-AUC 0.82). Thirst 0-9 scale (ROC-AUC 0.97 and 0.78 for ID and ED) and urine osmolality (ROC-AUC 0.99 and 0.81 for ID and ED) identified both dehydration types. However, only thirst 0-9 scale had a common dehydration threshold (>/=4; sensitivity and specificity of 100%, 87% and 71%, 87% for ID and ED). In conclusion, using a common dehydration threshold >/=4, the thirst 0-9 scale identified mild intracellular and extracellular dehydration with adequate diagnostic accuracy. In young healthy adults' thirst 0-9 scale is a valid and practical dehydration-screening tool.

Item Type: Article
Additional Information: Accepted author manuscript version reprinted, by permission, from International Journal of Sport Nutrition & Exercise Metabolism, 2019, 29 (6): 604-611pp-pp, https://doi.org/10.1123/ijsnem.2019-0022. © Human Kinetics, Inc. [or other copyright notice shown in journal, if different]
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences, 1116 Medical Physiology
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Human Kinetics
Related URLs:
Date Deposited: 15 Feb 2022 12:28
Last Modified: 15 Feb 2022 12:30
DOI or ID number: 10.1123/ijsnem.2019-0022
URI: https://researchonline.ljmu.ac.uk/id/eprint/16300
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