Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Collagen gene polymorphisms previously associated with resistance to soft-tissue injury are more common in competitive runners than non-athletes

Dines, HR, Nixon, J, Lockey, SJ, Herbert, AJ, Kipps, C, Pedlar, CR, Day, SH, Heffernan, SM, Antrobus, MR, Brazier, J, Erskine, RM, Stebbings, GK, Hall, ECR and Williams, AG (2022) Collagen gene polymorphisms previously associated with resistance to soft-tissue injury are more common in competitive runners than non-athletes. Journal of Strength and Conditioning Research. ISSN 1064-8011

Dines_et_al_2022_JSCR_accepted.pdf - Accepted Version

Download (381kB) | Preview


Single nucleotide polymorphisms (SNPs) of collagen genes have been associated with soft-tissue injury and running performance. However, their combined contribution to running performance is unknown. We investigated the association of two collagen gene SNPs with athlete status and performance in 1429 Caucasian participants, including 597 competitive runners (354 men, 243 women) and 832 non-athletes (490 men, 342 women). Genotyping for COL1A1 rs1800012 (C>A) and COL5A1 rs12722 (C>T) SNPs was performed by real-time polymerase chain reaction. The numbers of ‘injury-resistant’ alleles from each SNP, based on previous literature (rs1800012 A allele, rs12722 C allele), were combined as an injury-resistance score (RScore, 0 to 4; higher scores indicate injury-resistance). Genotype frequencies, individually and combined as RScore, were compared between cohorts and investigated for associations with performance via official race times. Runners had 1.34 times greater odds of being rs12722 CC homozygotes than non-athletes (19.7% vs. 15.5%, P=0.020) with no difference in rs1800012 genotype distribution (P=0.659). Fewer runners had RScore 0 (18.5% vs. 24.7%) and more had RScore 4 (0.6% vs. 0.3%) than non-athletes (P<0.001). Competitive performance was not associated with COL1A1 genotype (P=0.933), COL5A1 genotype (P=0.613) or RScore (P=0.477). Whilst not associated directly with running performance amongst competitive runners, a higher combined frequency of injury-resistant COL1A1 rs1800012 A and COL5A1 rs12722 C alleles in competitive runners than non-athletes suggests these SNPs may be advantageous via a mechanism that supports, but does not directly enhance, running performance.

Item Type: Article
Additional Information: This is the Accepted Manuscript of an article accepted for publishing in Journal of Strength and Conditioning Research. The Version of the Record is available at: https://doi.org/10.1519/JSC.0000000000004291
Uncontrolled Keywords: 1106 Human Movement and Sports Sciences, 1116 Medical Physiology
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Lippincott, Williams & Wilkins
Date Deposited: 15 Mar 2022 14:33
Last Modified: 07 Jun 2023 00:50
DOI or ID number: 10.1519/JSC.0000000000004291
URI: https://researchonline.ljmu.ac.uk/id/eprint/16497
View Item View Item