Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

Association of gene polymorphisms with body weight changes in prediabetic patients

Valeeva, FV, Medvedeva, MS, Khasanova, KB, Valeeva, EV, Kiseleva, TA, Egorova, ES, Pickering, C and Ahmetov, II (2022) Association of gene polymorphisms with body weight changes in prediabetic patients. Molecular Biology Reports. ISSN 0301-4851

Association of gene polymorphisms with body weight changes in prediabetic patients.pdf - Published Version
Available under License Creative Commons Attribution.

Download (688kB) | Preview


Background: Recent research has demonstrated that Type 2 Diabetes (T2D) risk is influenced by a number of common polymorphisms, including MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146. Knowledge of the association between these single nucleotide polymorphisms (SNPs) and body weight changes in different forms of prediabetes treatment is still limited. The aim of this study was to investigate the association of polymorphisms within the MC4R, PPARG, and TCF7L2 genes on the risk of carbohydrate metabolism disorders and body composition changes in overweight or obese patients with early carbohydrate metabolism disorders. Methods and results: From 327 patients, a subgroup of 81 prediabetic female patients (48.7 ± 14.8 years) of Eastern European descent participated in a 3-month study comprised of diet therapy or diet therapy accompanied with metformin treatment. Bioelectrical impedance analysis and genotyping of MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146 polymorphisms were performed. The MC4R CC and TCF7L2 TT genotypes were associated with increased risk of T2D (OR = 1.46, p = 0.05 and OR = 2.47, p = 0.006, respectively). PPARG CC homozygotes experienced increased weight loss; however, no additional improvements were experienced with the addition of metformin. MC4R TT homozygotes who took metformin alongside dietary intervention experienced increased weight loss and reductions in fat mass (p < 0.05). Conclusions: We have shown that the obesity-protective alleles (MC4R T and PPARG C) were positively associated with weight loss efficiency. Furthermore, we confirmed the previous association of the MC4R C and TCF7L2 T alleles with T2D risk.

Item Type: Article
Uncontrolled Keywords: 0601 Biochemistry and Cell Biology
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sport & Exercise Sciences
Publisher: Springer
Date Deposited: 01 Apr 2022 09:04
Last Modified: 01 Apr 2022 09:15
DOI or ID number: 10.1007/s11033-022-07254-y
URI: https://researchonline.ljmu.ac.uk/id/eprint/16569
View Item View Item