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Qin, S, Tian, Z, Boidin, M, Buckley, BJR, Thijssen, DHJ and Lip, GYH (2022) Irisin is an effector molecule in exercise rehabilitation following myocardial infarction (Review). Frontiers in Physiology, 13. ISSN 1664-042X
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Irisin is an effector molecule in exercise rehabilitation following myocardial infarction (Review).pdf - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Background: Regular exercise is an effective non-pharmacological therapy for treatment and prevention of cardiovascular diseases (CVD). The therapeutic benefits of exercise are mediated partly through improved vascular and increase in metabolic health. Release of exercise-responsive myokines, including irisin, is associated with beneficial effects of exercise in CVD patients.
Observations: The present review provides an overview of the role of exercise in cardiac rehabilitation of patients with myocardial infarction (MI). Further, the role of irisin as a motion-responsive molecule in improving vascular and metabolic health is explored. Possible mechanism of cardioprotective effect of irisin-mediated exercise on myocardial infarction are also summarized in this review.
Conclusions and significance of the review: Irisin is associated with reduced inflammation, antioxidant properties, and anti-apoptosis effect, implying that it is a potential key mediator of the beneficial effects of exercise on vascular and metabolic health. The findings show that irisin is a promising therapeutic target for treatment of cardiovascular patients, particularly post-MI. Further research should be conducted to elucidate the potential mechanisms of cardioprotective effects of irisin and explored whether irisin induced by exercise exerts rehabilitation effects post-MI.
| Item Type: | Article |
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| Uncontrolled Keywords: | 0606 Physiology; 1116 Medical Physiology; 1701 Psychology |
| Subjects: | R Medicine > RC Internal medicine > RC1200 Sports Medicine |
| Divisions: | Sport & Exercise Sciences |
| Publisher: | Frontiers Media |
| SWORD Depositor: | A Symplectic |
| Date Deposited: | 06 Jun 2022 11:07 |
| Last Modified: | 29 Jun 2022 09:00 |
| DOI or ID number: | 10.3389/fphys.2022.935772 |
| URI: | https://researchonline.ljmu.ac.uk/id/eprint/17003 |
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