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Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities

Zafar, S, Sarfraz, I, Rasul, A, Shah, MA, Hussain, G, Zahoor, MK, Shafiq, N, Riaz, A, Selamoglu, Z and Sarker, SD (2020) Osthole: A Multifunctional Natural Compound with Potential Anticancer, Antioxidant and Anti-inflammatory Activities. Mini-Reviews in Medicinal Chemistry, 21 (18). pp. 2747-2763. ISSN 1389-5575

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Nature has always proved to be a significant reservoir of bioactive scaffolds that have been used for the discovery of drugs since times. Medicinal plants continue to be a solid niche for biologically active and therapeutically effective chemical entities, opening up new avenues for the successful treatment of several human diseases. The contribution of plant-derived compounds to drug discovery, either in their original or in the semi-synthetic derivative form, extends far back in time. This review aims to focus on the sources, biological, and pharmacological profile of a pharmacologically active plant-derived coumarin, osthole, which is an important component of numerous remedial plants such as Cnidium monnieri. Several studies have revealed that osthole possess pharmacological properties such as anticancer, antioxidant, anti-hyperglycemic, neuroprotective, and antiplatelet. Osthole has been reported to regulate various signaling pathways, which in turn modulate several apoptosis-related pro-teins, cell cycle regulators, protein kinases, transcriptional factors, cytokines, and growth receptors affiliated with inflammation, proliferation and several other ailments. Osthole is known to halt proliferation and metastasis of cancerous cells by arresting the cell cycle and inducing apoptosis. The data in this review paper supports the pharmacological potential of osthole but further experimentation, biosafety profiling and synergistic effects of this compound need to be focused by the researchers to understand the full spectrum of pharmacological potential of this therapeutically potent compound.

Item Type: Article
Additional Information: The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/10.2174/1389557520666200709175948
Uncontrolled Keywords: Science & Technology; Life Sciences & Biomedicine; Chemistry, Medicinal; Pharmacology & Pharmacy; Osthole; anti-inflammatory; antioxidant; anticancer; anti-diabetic; neuroprotective; ISCHEMIA-REPERFUSION INJURY; NF-KAPPA-B; BREAST-CANCER CELLS; INDUCED FATTY LIVER; TRADITIONAL CHINESE MEDICINE; PI3K/AKT SIGNALING PATHWAY; ACUTE LUNG INJURY; CNIDIUM-MONNIERI; FRUCTUS-CNIDII; OXIDATIVE STRESS; Animals; Humans; Cnidium; Coumarins; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Products; Antioxidants; Osthole; anti-diabetic; anti-inflammatory; anticancer; antioxidant; neuroprotective.; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Biological Products; Cnidium; Coumarins; Humans; 0304 Medicinal and Biomolecular Chemistry; 1115 Pharmacology and Pharmaceutical Sciences; Medicinal & Biomolecular Chemistry
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: Bentham Science Publishers
SWORD Depositor: A Symplectic
Date Deposited: 16 Jun 2022 12:06
Last Modified: 16 Jun 2022 12:15
DOI or ID number: 10.2174/1389557520666200709175948
URI: https://researchonline.ljmu.ac.uk/id/eprint/17096
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