Facial reconstruction

Search LJMU Research Online

Browse Repository | Browse E-Theses

A topographical and physiological exploration of C-tactile afferents and their response to menthol and histamine

Loken, LS, Wasling, HB, Olausson, H, McGlone, FP and Wessberg, J (2022) A topographical and physiological exploration of C-tactile afferents and their response to menthol and histamine. Journal of Neurophysiology, 127 (2). pp. 463-473. ISSN 0022-3077

A topographical and physiological exploration of C-tactile afferents and their response to menthol and histamine.pdf - Published Version
Available under License Creative Commons Attribution.

Download (2MB) | Preview
Open Access URL: https://doi.org/10.1152/jn.00310.2021 (Published version)


Unmyelinated tactile (C-tactile or CT) afferents are abundant in arm hairy skin and have been suggested to signal features of social affective touch. Here, we recorded from unmyelinated low-threshold mechanosensitive afferents in the peroneal and radial nerves. The most distal receptive fields were located on the proximal phalanx of the third finger for the superficial branch of the radial nerve and near the lateral malleolus for the peroneal nerve. We found that the physiological properties with regard to conduction velocity and mechanical threshold, as well as their tuning to brush velocity, were similar in CT units across the antebrachial (n = 27), radial (n = 8), and peroneal (n = 4) nerves. Moreover, we found that although CT afferents are readily found during microneurography of the arm nerves, they appear to be much more sparse in the lower leg compared with C-nociceptors. We continued to explore CT afferents with regard to their chemical sensitivity and found that they could not be activated by topical application to their receptive field of either the cooling agent menthol or the pruritogen histamine. In light of previous studies showing the combined effects that temperature and mechanical stimuli have on these neurons, these findings add to the growing body of research suggesting that CT afferents constitute a unique class of sensory afferents with highly specialized mechanisms for transducing gentle touch.

Item Type: Article
Uncontrolled Keywords: affective touch; CHANNELS; CT afferent; CUTANEOUS MECHANORECEPTORS; histamine; INNERVATION; Life Sciences & Biomedicine; menthol; NEURONS; Neurosciences; Neurosciences & Neurology; peroneal nerve; Physiology; Science & Technology; SENSATION; STIMULI; TEMPERATURE; TOUCH; TRPM8; UNMYELINATED AFFERENTS; Science & Technology; Life Sciences & Biomedicine; Neurosciences; Physiology; Neurosciences & Neurology; affective touch; CT afferent; histamine; menthol; peroneal nerve; UNMYELINATED AFFERENTS; CUTANEOUS MECHANORECEPTORS; TOUCH; TRPM8; INNERVATION; TEMPERATURE; SENSATION; CHANNELS; STIMULI; NEURONS; Leg; Afferent Pathways; Nerve Fibers, Unmyelinated; Mechanoreceptors; Nociceptors; Radial Nerve; Peroneal Nerve; Humans; Menthol; Histamine; Histamine Agonists; Antipruritics; Affect; Adult; Female; Male; Touch Perception; Young Adult; CT afferent; affective touch; histamine; menthol; peroneal nerve; Adult; Affect; Afferent Pathways; Antipruritics; Female; Histamine; Histamine Agonists; Humans; Leg; Male; Mechanoreceptors; Menthol; Nerve Fibers, Unmyelinated; Nociceptors; Peroneal Nerve; Radial Nerve; Touch Perception; Young Adult; Neurology & Neurosurgery; 11 Medical and Health Sciences; 17 Psychology and Cognitive Sciences
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Psychology (from Sep 2019)
Publisher: American Physiological Society
SWORD Depositor: A Symplectic
Date Deposited: 21 Sep 2022 10:56
Last Modified: 21 Sep 2022 11:00
DOI or ID number: 10.1152/jn.00310.2021
URI: https://researchonline.ljmu.ac.uk/id/eprint/17644
View Item View Item