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Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation

Mantle, D and Hargreaves, IP (2022) Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation. International Journal of Molecular Sciences, 23 (20).

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<Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders, including Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, multisystem atrophy, and progressive supranuclear palsy. This article is concerned specifically with mitochondrial dysfunction as defined by reduced capacity for ATP production, the role of depleted levels of key nutritionally related metabolites, and the potential benefit of supplementation with specific nutrients of relevance to normal mitochondrial function in the above neurodegenerative disorders. The article provides a rationale for a combination of CoQ10, B-vitamins/NADH, L-carnitine, vitamin D, and alpha-lipoic acid for the treatment of the above neurodegenerative disorders.

Item Type: Article
Uncontrolled Keywords: Chemical Physics; 0399 Other Chemical Sciences; 0604 Genetics; 0699 Other Biological Sciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Pharmacy & Biomolecular Sciences
Publisher: MDPI AG
SWORD Depositor: A Symplectic
Date Deposited: 27 Oct 2022 14:30
Last Modified: 27 Oct 2022 14:45
DOI or ID number: 10.3390/ijms232012603
URI: https://researchonline.ljmu.ac.uk/id/eprint/17952
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