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Coenzyme Q10: Role in Less Common Age-Related Disorders

Mantle, D and Hargreaves, IP (2022) Coenzyme Q10: Role in Less Common Age-Related Disorders. Antioxidants, 11 (11).

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Open Access URL: https://doi.org/10.3390/antiox11112293 (Published version)


In this article we have reviewed the potential role of coenzyme Q10 (CoQ10) in the pathogenesis and treatment of a number of less common age-related disorders, for many of which effective therapies are not currently available. For most of these disorders, mitochondrial dysfunction, oxidative stress and inflammation have been implicated in the disease process, providing a rationale for the potential therapeutic use of CoQ10, because of its key roles in mitochondrial function, as an antioxidant, and as an anti-inflammatory agent. Disorders reviewed in the article include multi system atrophy, progressive supranuclear palsy, sporadic adult onset ataxia, and pulmonary fibrosis, together with late onset versions of Huntington’s disease, Alexander disease, lupus, anti-phospholipid syndrome, lysosomal storage disorders, fibromyalgia, Machado-Joseph disease, acyl-CoA dehydrogenase deficiency, and Leber’s optic neuropathy.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Pharmacy & Biomolecular Sciences
Publisher: MDPI AG
SWORD Depositor: A Symplectic
Date Deposited: 25 Nov 2022 12:09
Last Modified: 25 Nov 2022 12:15
DOI or ID number: 10.3390/antiox11112293
URI: https://researchonline.ljmu.ac.uk/id/eprint/18220
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